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'Candyflipping': synergistic discriminative effect of LSD and MDMA (1998)

'Candyflipping': synergistic discriminative effect of LSD and MDMA (1998)

  1. Alfa
    Eur J Pharmacol. (javascript:AL_get(this, 'jour', 'Eur J Pharmacol.');) 1998 Jan 12;341(2-3):131-4

    Schechter MD (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).

    The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect

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