Candyflipping: Synergistic discriminative effect of LSD and MDMA

co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like effect

  1. Pjotr777
    Study Author(s):
    Martin D. Schechter
    Journal Name:
    European Journal of Pharmacology 341 1998 131–134
    Publication Date:
    28 October 1997
    PMID:
    9543229
    Abstract
    The co-administration of d-lysergic acid diethylamide (LSD; `Acid') and 3,4-methylenedioxymethamphetamine (MDMA; `Ecstasy'; `XTC'), has reached a prevalence that has allowed for the street terminology `candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect.