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Cannabinoids and the gastrointestinal tract

Cannabinoids and the gastrointestinal tract

  1. salviablue
    Cannabinoids and the gastrointestinal tract
    R G PERTWEE
    Department of Biomedical Sciences,
    Institute of Medical Sciences, University of Aberdeen

    "Conclusions
    There is little doubt from the animal data described in this
    review that the endocannabinoid system extends into the
    enteric nervous system where it exerts an inhibitory influ-
    ence on the processes of gastric emptying and peristalsis.
    These eVects on gastrointestinal motility seem to be largely
    mediated by peripheral CB1 receptors that inhibit ongoing
    contractile transmitter release when activated. Gastric acid
    secretion can also be inhibited in response to CB1 receptor
    activation although the underlying mechanisms have yet to
    be elucidated in detail.
    "