1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Cannabinoids for control of chemotherapy induced nausea and vomiting quantitative systematic review

Cannabinoids for control of chemotherapy induced nausea and vomiting quantitative systematic review

  1. Docta
    Sections of the medical establishment have pleaded for legalisation of cannabis (marijuana) for medical use.1,2 Interest in cannabis and its active constituents, cannabinoids, as therapeutic agents has increased recently.3 Dronabinol (Δ9-tetrahydrocannabinol, one of the main ingredients in cannabis) and the synthetic cannabinoid compound nabilone are available by prescription in some countries.

    A Medline search using the terms cannabis, cannabinoids, marijuana, and marijuana smoking found 6059 articles from 1975 to 1996; most were on the antiemetic properties of cannabis.4 Surveys of oncologists' choices of treatment for emesis caused by chemotherapy came to divergent results.4 In one, 63% of responding oncologists agreed with the statement affirming the efficacy of cannabis for treatment of emesis.5 In another, oncologists ranked dronabinol or smoked cannabis only ninth out of nine choices for mild nausea, and sixth out of nine for severe nausea.6 An early literature review on cannabinoids and emesis concluded that orally administered dronabinol represented a major advance in antiemetic therapy.7

    We searched systematically for the strongest evidence of efficacy and harm of cannabis in patients having chemotherapy. We examined whether there is any evidence that cannabis is antiemetic when given concomitantly with emetogenic chemotherapy, how well cannabis works in this setting compared with placebo or conventional antiemetics, the evidence for a dose-response relation, and the profile of adverse effects.
Tags: