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Cannabis Use is Quantitatively Associated with Nucleus Accumbens and Amygdala Abnormalities in Young

Cannabis Use is Quantitatively Associated with Nucleus Accumbens and Amygdala Abnormalities in Young

  1. NeuroChi
    Marijuana is the most commonly used illicit drug in the United States, but little is known about its effects on the human brain, particularly on reward/aversion regions implicated in addiction, such as the nucleus accumbens and amygdala. Animal studies show structural changes in brain regions such as the nucleus accumbens after exposure to 9-tetrahydrocannabinol,but less is known about cannabis use and brain morphometry in these regions in humans.We collected high-resolution MRI scans on young adult recreational marijuana users and nonusing controls and conducted three independent analyses of morphometry in these structures: (1) gray matter density using voxel-based morphometry, (2) volume (total brain and regional volumes), and (3) shape (surface morphometry). Gray matter density analyses revealed greater gray matter density in marijuana users than in control participants in the left nucleus accumbens extending to subcallosal cortex, hypothalamus, sublenticular extended amygdala, and left amygdala, even after controlling for age, sex, alcohol use, and cigarette smoking. Trend-level effects were observed for a volume increase in the left nucleus accumbens only. Significant shape differences were detected in the left nucleus accumbens and right amygdala. The left nucleus accumbens showed salient exposure-dependent alterations across all three measures and an altered multimodal relationship across measures in the marijuana group. These data suggest that marijuana exposure, even in young recreational users, is associated with exposure-dependent alterations of the neural matrix of core reward structures and is consistent with animal studies of changes in dendritic arborization.

Recent Reviews

  1. Docta
    Docta
    5/5,
    Version: 2014-04-17
    Still in my first hours of evaluating this peer review submission: [FONT=MyriadMM-RegularCondensed][FONT=MyriadMM-RegularCondensed]The Journal of Neuroscience, April 16, 2014 [/FONT][/FONT][FONT=MyriadMM-RegularCondensed][FONT=MyriadMM-RegularCondensed]• [/FONT][/FONT][FONT=MyriadMM-RegularCondensed][FONT=MyriadMM-RegularCondensed]34(16):5529 –5538 • 5529[/FONT][/FONT]

    I find myself trying to comprehend a research paper of intellect beyond my ability's. I have four reference text books open to assist me to decipher and understand the ramification of these findings, even so I've only scratched the surface.

    This one is a game changer.

    P.S

    [FONT=MyriadMM-BoldCondensed][SIZE=1][FONT=MyriadMM-BoldCondensed][SIZE=1][SIZE=2]This is the single largest number of Harvard Fellow I have seen attached to a document.[/SIZE][/SIZE][/FONT][/SIZE][/FONT]
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