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Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke

Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke

  1. lostmente
    Tobacco smoking is responsible for a vast array of diseases, particularly chronic bronchitis and lung cancer. It is
    still unclear which constituent(s) of the smoke is responsible for its toxicity. The authors decided to focus on carbon dioxide, since its level of concentration in mainstream cigarette smoke is about 200 times higher than in the
    atmosphere. The authors previously demonstrated that inhalation of carbon dioxide concentrations above 5%
    has a deleterious effect on lungs. In this study, the authors assessed the inflammatory potential of carbon dioxide
    contained in cigarette smoke. Mice were exposed to cigarette smoke containing a high or reduced CO2
    level by
    filtration through a potassium hydroxyde solution. The inflammatory response was evaluated by histological
    analysis, protein phosphatase 2 A (PP2A) and nuclear factor (NF)-κB activation, and proinflammatory cytokine
    secretion measurements. The data show that the toxicity of cigarette smoke may be largely due to its high level of
    CO2
    . Pulmonary injuries consequent to tobacco smoke inhalation observed by histology were greatly diminished
    when CO2
    was removed. Cigarette smoke exposure causes an inflammatory response characterized by PP2A and
    NF-κB activation followed by proinflammatory cytokine secretion. This inflammatory response was reduced when
    the cigarette smoke was filtered through a potassium hydroxide column, and reestablished when CO2
    was injected
    downstream from the filtration column. Given that there is an extensive literature linking a chronic inflammatory
    response to the major smoking-related diseases, these data suggest that carbon dioxide may play a key role in
    the causation of these diseases by tobacco smoking.
    Keywords: Cigarette; lung; inflammation; PP2A; NFκB