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Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment (2001)

Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment (2001)

  1. Jatelka
    Alkaloids Chem Biol. 2001;56:135-53

    Onaivi ES, Akinshola BE, Ali SF.

    Looks at the molecular biology of Ibogaine
    One new hypothesis being explored is that both the peripheral and central actions of abused substances contribute to drug addiction. It is suggested that an effective therapeutic agent for addiction may be obtained only when both peripheral and central actions of the processes contributing to addictions are considered. There is evidence from animal studies, and from anecdotal human studies, that the alkaloid ibogaine, and perhaps its metabolites, alter or regulate gene expression and signal transduction pathways and restore altered neuroadaptive processes arising from the loss of control due to drug addiction. We and others have observed that treatment with cocaine influences the regulation of certain genes in the brain, as indicated by the activation and inhibition of the expression sequence tags (ESTs) that have been isolated. The behavioral data presented here supports the notion that ibogaine restores the behavioral and neurogenetic alterations resulting from exposure to cocaine.
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