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Changes in heroin self-administration by a rhesus monkey after morphine immunisation (1974)

Changes in heroin self-administration by a rhesus monkey after morphine immunisation (1974)

  1. Calliope
    Nature 252, 708 - 710 (20 December 1974); doi:10.1038/252708a0

    Bonese KF, Wainer BH, Fitch FW, et al.

    Abstract
    We have investigated in one primate the effects of immunization against an opiate on the self-administration of these drugs. Using the rhesus monkey, which will self-administer various drugs, including opiates and psychomotor stimulants, we have followed the response for heroin before and after immunization against morphine. Results indicate that antibodies against morphine can block those effects of heroin on the central nervous system (CNS) that maintain self-administration behavior.