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Chemoinformatics: Where 'magic bullets' go astray

Chemoinformatics: Where 'magic bullets' go astray

  1. ThirdEyeFloond
    Nature Reviews Drug Discovery 8, 933 (December 2009) | doi:10.1038/nrd3059

    Alexandra Flemming

    The concept of 'magic bullets' — drugs with high specificity for their target — was introduced by Paul Ehrlich almost 100 years ago. Since then, it has become clear that most drugs exhibit some degree of polypharmacology, with off-target effects that can contribute to unwanted side effects, but also to the drug's effectiveness.

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