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Chronic methamphetamine exposure alters immune function in normal and retrovirus-infected mice (2002

Chronic methamphetamine exposure alters immune function in normal and retrovirus-infected mice (2002

  1. mersann
    Authors: Qianli Yu, Dongqin Zhang, Michael Walston, Jin Zhang, Yingyin Liu, Ronald R. Watson
    Abstract beginning: Methamphetamine (MA) abuse represents a growing problem in the USA with an increase of sudden death. To evaluate the immune function alterations due to chronic methamphetamine use, we examined C57BL/C mice with LP-BM5 retrovirus infection plus methamphetamine exposure. Mice were randomly assigned to the following groups: placebo, placebo retrovirus-infected, uninfected MA treated and retrovirus infected MA treated. Placebo, MA-treated groups were intraperitoneally injected with saline, MA, respectively, with a gradually increasing dose from 15 to 40 mg/kg for 12 weeks (5 days/week). Con A- and LPS-induced mitogenesis of splenocytes, cytokine production by splenocytes culture and lipid peroxides in the liver were measured. Heart tissue histopathology was analyzed in all the groups with murine cytomegalovirus (CMV) superinfection.