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Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects.

Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects.

  1. ThirdEyeFloond
    Pharmacol Biochem Behav. 2005 Sep;82(1):90-7. Epub 2005 Aug 19.

    Newton TF, De La Garza R 2nd, Kalechstein AD, Nestor L.

    The stimulant effects of cocaine and methamphetamine are mediated by changes in synaptic concentrations of brain monoamines; however, the drugs alter monoamine levels via different mechanisms. This study examined the subjective and cardiovascular responses produced by investigational administration of cocaine or methamphetamine, in order to examine the onset and patterns of subjective and cardiovascular responses. Subjects included 14 non-treatment seeking cocaine-dependent and 11 non-treatment seeking methamphetamine-dependent volunteers. As part of ongoing research studies, cocaine and methamphetamine subjects received cocaine (40 mg, IV) or methamphetamine (30 mg, IV), respectively. Subjective and cardiovascular responses were assessed for 30 min and 60 min, respectively. The data reveal significant within groups differences for all subjective effects and cardiovascular effects (p