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Comparative Amnesic and Sedative Effects of Lorazepam and Oxazepam in Healthy Volunteers

Comparative Amnesic and Sedative Effects of Lorazepam and Oxazepam in Healthy Volunteers

  1. Bajeda
    Curran H.V., Gorenstein C., & Lader M. (1993). Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers. Journal of Psychopharmacology, 7(3): 249-256.

    Abstract: Compared the effects of oxazepam and its chlorinated derivative, lorazepam, with a placebo on memory, mood, and psychomotor function. 36 adult volunteers completed a battery of tests before and 2 hrs, 15 min after drug administration. Lorazepam 2 mg produced more profound subjective and motor sedation than oxazepam 30 mg, and this in turn produced a similar, global pattern of impairments across a wide range of tasks. However, lorazepam produced greater decrements than oxazepam on a task involving episodic memory even when sedative effects were partialled out. This finding may reflect either differential task sensitivities or a contribution of priming to performance on the explicit memory task.