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Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation

Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation

  1. Jatelka
    J Pharmacol Exp Ther. 2000 May;293(2):435-43

    Greenblatt DJ, Harmatz JS, von Moltke L, Wright CE, Durol AL, Harrel-Joseph LM, Shader RI.

    Eighteen healthy volunteers (10 men and 8 women) participated in a single-dose, double-blind, three-way crossover pharmacokinetic and pharmacodynamic study. Treatment conditions were 0.25 mg of triazolam, a full-agonist benzodiazepine ligand; 10 mg of zolpidem, an imidazopyridine having relative selectivity for the type 1 benzodiazepine receptor subtype; and placebo. Weight-normalized clearance of triazolam was higher in women than in men (8.7 versus 5. 5 ml/min/kg), but the difference was not significant. In contrast, zolpidem clearance was lower in women than in men (3.5 versus 6.7 ml/min/kg, P