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Comparative Lethality of Coca and Cocaine (1982)

Comparative Lethality of Coca and Cocaine (1982)

  1. Bajeda
    Pharmacology Biochemistry and Behaviour 1982 Nov;17(5):1087-8

    Bedford JA (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Turner CE (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Elsohly HN (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).

    The 24 hour lethal effects of cocaine were compared to those of a crude ethanol extract of the coca leaf (Erthroxyhm coea) in male, Swiss mice. Various doses of cocaine HCI and coca leaf extracts suspended in a Tween 60, Arlacel 83, and distilled water vehicle were injected IP into groups of 10 mice. The LD.~0 for cocaine was 95.1 mg/kg. The LDs0 for the coca extract was 3450 mg/kg. The LD~o of the extract based on its cocaine content was 31.4 mg/kg. The results clearly indicate that the coca leaf contains constituents other than cocaine that can contribute to a toxic effect of the plant.