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Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various e

Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various e

  1. ZenobiaSky
    Journal of Nuclear Medicine . 2002 May;43(5):678-92
    Szabo Z, McCann UD, Wilson AA, Scheffel U, Owonikoko T, Mathews WB , Ravert HT, Hilton J , Dannals RF, Ricaurte GA .
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins School of Medicine,

    Abstract
    There has been considerable interest in the development of a PET radioligand selective for the serotonin (5-hydroxytryptamine [5-HT]) transporter (SERT) that can be used to image 5-HT neurons in the living human brain. The most widely used SERT radiotracer to date, trans-1,2,3,5,6,10-beta-hexahydro-6-[4-(methylthio)phenyl[pyrrolo-[2,1-a]isoquinoline ((+)-(11)C-McN5652), has been successful in this regard but may have some limitations. Recently, another promising SERT radiotracer, 3-(11)C-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile ((11)C-DASB), has been described. The purpose of this study was to compare and contrast (+)-(11)C-McN5652 and (11)C-DASB under various experimental conditions.