1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.

Comparison of subjective effects of DXM in alcoholics and healthy volunteers (2005)

Comparison of subjective effects of DXM in alcoholics and healthy volunteers (2005)

  1. Paracelsus

    Steubing, Dieter. Vergleich der induzierten subjektiven Effekte bei Alkoholikern und gesunden Probanden nach experimenteller Challenge mit dem NMDA-Antagonisten Dextromethorphan. Dissertation der Ludwig-Maximilians-Universit√§t. M√ľnchen, 2005.

    Analyzes the subjective effects of low-dose DXM (2 mg/kg) in abstinent alcoholics and healthy volunteers. Records detailed values of anxiety, stimulation, sedation, analgesia, dysphoria, euphoria, etc scales.
    Concludes that abstinent alcoholics experience overall less subjective effects. The author hypothesizes that this is due to NMDA receptor insensitivity caused by chronic alcohol abuse (alcohol is a NMDA antagonist).

    Plasma levels of DXM, dextrorphan and 3-hydroxymorphinan (at 60, 120, and 180 minutes after administration) were also recorded.