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Comparison of subjective effects of DXM in alcoholics and healthy volunteers (2005)

Comparison of subjective effects of DXM in alcoholics and healthy volunteers (2005)

  1. Paracelsus
    FILE IN GERMAN.

    Steubing, Dieter. Vergleich der induzierten subjektiven Effekte bei Alkoholikern und gesunden Probanden nach experimenteller Challenge mit dem NMDA-Antagonisten Dextromethorphan. Dissertation der Ludwig-Maximilians-Universit√§t. M√ľnchen, 2005.

    Analyzes the subjective effects of low-dose DXM (2 mg/kg) in abstinent alcoholics and healthy volunteers. Records detailed values of anxiety, stimulation, sedation, analgesia, dysphoria, euphoria, etc scales.
    Concludes that abstinent alcoholics experience overall less subjective effects. The author hypothesizes that this is due to NMDA receptor insensitivity caused by chronic alcohol abuse (alcohol is a NMDA antagonist).

    Plasma levels of DXM, dextrorphan and 3-hydroxymorphinan (at 60, 120, and 180 minutes after administration) were also recorded.
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