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Concise Large-Scale Synthesis of Psilocin and Psilocybin

Concise Large-Scale Synthesis of Psilocin and Psilocybin

  1. Dr. Jackal
    Osamu Shirota, Wataru Hakamata, and Yukihiro Goda

    The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic purification. The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses.