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Decoding BDNF-LTP Coupling in Cocaine Addiction

Decoding BDNF-LTP Coupling in Cocaine Addiction

  1. Terrapinzflyer
    Decoding BDNF-LTP Coupling in Cocaine Addiction
    Li-Min Mao,1 Eugene E. Fibuch,2 and John Q. Wang1,2,* 1Department of Basic Medical Science 2Department of Anesthesiology School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA
    DOI 10.1016/j.neuron.2010.08.036

    BDNF is a neurotrophic peptide that regulates synaptic plasticity. New work by Lu and coworkers in this issue of Neuron now identifies BDNF as a gatekeeper of synaptic and behavioral plasticity in cocaine sensitization. In the medial prefrontal cortex, upregulated BDNF facilitates LTP and contributes to neurobehavioral adaptations to psychostimulants.

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