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Delta9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and

Delta9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and

  1. ThirdEyeFloond
    The Journal of Neuroscience, June 1, 2002, 22(11):4720–4727

    Peter M. Zygmunt, David A. Andersson, and Edward D. Högestätt

    Delta9-tetrahydrocannabinol (THC) produces analgesia,
    its effects on nociceptive primary afferents are unknown. These
    neurons participate not only in pain signaling but also in the
    local response to tissue injury. Here, we show that THC and
    cannabinol induce a CB1/CB2 cannabinoid receptorindependent
    release of calcitonin gene-related peptide from capsaicin-sensitive perivascular sensory nerves. Other psychotropic cannabinoids cannot mimic this action. The vanilloid
    receptor antagonist ruthenium red abolishes the responses to
    THC and cannabinol. However, the effect of THC on sensory
    nerves is intact in vanilloid receptor subtype 1 gene knock-out
    mice. The THC response depends on extracellular calcium but
    does not involve known voltage-operated calcium channels,
    glutamate receptors, or protein kinases A and C. These results
    may indicate the presence of a novel cannabinoid receptor/ion
    channel in the pain pathway.

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