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Design, Synthesis and Pharmacology of Cannabimimetic Indoles

Design, Synthesis and Pharmacology of Cannabimimetic Indoles

  1. helikophis
    Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the I-butyl. pentyl and hexyl analogs. A rationalixation for the alignment of these indoles with traditional cannabinoids is presented.