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Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine

Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine

  1. ThirdEyeFloond
    doi:10.1016/j.forsciint.2009.04.001

    Kei Zaitsu, Munehiro Katagi, Hiroe T. Kamata, Tooru Kamata, Noriaki Shima, Akihiro Miki, Hitoshi Tsuchihashi and Yasushige Mori

    This is the first report on identifying the specific metabolites of the new designer drugs 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one (bk-MBDB) and 2-ethylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (bk-MDEA) in human urine using synthesized standards. Based on GC/MS and LC/MS, we identified N-dealkylation, demethylenation followed by O-methylation, and β-ketone reduction as their major metabolic pathways. The quantitative analyses by LC/MS revealed that both demethylenation followed by O-methylation and β-ketone reduction were superior to N-dealkylation and that both bk-MBDB and bk-MDEA were mainly metabolized into their corresponding 4-hydroxy-3-methoxy metabolites (4-OH-3MeO metabolites). After hydrolysis, the concentrations of 4-OH-3MeO metabolites and 3-hydroxy-4-methoxy metabolites of both bk-MBDB and bk-MDEA dramatically increased, suggesting that the metabolites mainly exist as their conjugates.
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