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Dextromethorphan Potentiation of d-Amphetamine-Induced Behavior and Neurodegeneration in Rats

Dextromethorphan Potentiation of d-Amphetamine-Induced Behavior and Neurodegeneration in Rats

  1. Bajeda
    Experimental and Clinical Psychopharmacology 1994 2;2, 194-205

    Lawrence J Ryan andMichael G Wilson

    Dextromethorphan (25-200 mg/kg/day) potentiated the behavioral and toxic
    effects of d-amphetamine sulfate (7-35 mg/kg/day). Dextromethorphan shifted d-amphetamine-induced behaviors to resemble higher dose behaviors, though there was no dose effect of dextromethorphan. Dextromethorphan increased the incidence of neurodegeneration in the neostriatum and the cerebral cortex (determined histologically) at every dose of d-amphetamine.