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Diazepam Decreases Action Potential Firing of Neocortical Neurons via Two Distinct Mechanisms (2010)

Diazepam Decreases Action Potential Firing of Neocortical Neurons via Two Distinct Mechanisms (2010)

  1. Calliope
    Anesthesia and analgesia, 2010, Vol.111(6), pp.1394-9.

    Drexler, Berthold ; Zinser, Stefan ; Hentschke, Harald ; Antkowiak, Bernd

    Abstract
    Benzodiazepines are widely used in clinical anesthesia as premedication, but also to induce general anesthesia. Recent in vitro studies suggest that γ-aminobutyric acid type A receptors, harboring a classical high-affinity benzodiazepine binding site, possess another "nonclassical" binding site for benzodiazepines. At present, it is unclear if, and to what extent, this novel nonclassical binding site is of relevance for the actions of benzodiazepines in the central nervous system.