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Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives

Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives

  1. Anonymous
    Life Sci. 1977 Aug 15;21(4):569-75.
    Nichols DE, Shulgin AT, Dyer DC.

    Octanol-water partition coefficients (log P) were determined for a series of substituted psychotomimetic phenethylamine derivatives. A relationship was established between log P, steric bulk in the para-position and the ability to stimulate serotonin (5-HT) receptors in an in vitro sheep umbilical artery preparation. It appears that Log P values and in vitro activity in this preparation may be useful in predicting hallucinogenic potency in man.
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