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Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharm

Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharm

  1. ThirdEyeFloond
    Bioorganic & Medicinal Chemistry Letters
    Volume 19, Issue 1, 1 January 2009, Pages 31-35

    Isaac E. Marx, Erin F. DiMauro, Alan Cheng, Renee Emkey, Stephen A. Hitchcock, Liyue Huang, Ming Y. Huang, Jason Human, Josie H. Lee, Xingwen Li, Matthew W. Martin, Ryan D. White, Robert T. Fremeau Jr.f and Vinod F. Patel


    Abstract

    A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure–activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
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