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Discriminative stimulus effects of caffeine: Tolerance and cross-tolerance with methylphenidate.

Discriminative stimulus effects of caffeine: Tolerance and cross-tolerance with methylphenidate.

  1. testodan
    Twice daily injection of caffeine (30 mg/kg) for 3-1/2
    days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from lO mg/kg of caffeine. The latter group was also tested for cross-tolerance with methylphenidate,
    a drug that generalizes completely with caffeine.