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Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differe

Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differe

  1. Calliope
    Cancer Chemother Pharmacol 40 (3): 233–8, doi:10.1007/s002800050652, PMID 9219507

    Sugimachi K, Maehara Y, Ogawa M, Kakegawa T, Tomita M

    ABSTRACT
    A retrospective analysis of postoperative chemotherapy had shown the continuous administration of UFT, an oral preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) and uracil at a molar ratio of 1:4, to be effective for poorly differentiated gastric cancer. We therefore sought to determine prospectively the effective dose of postoperative chemotherapy with UFT for patients with poorly differentiated gastric cancer following a curative resection. We determined the effect of the combined intravenous administration of mitomycin C (MMC) and oral treatment with protein-bound polysaccharide Kreha (PSK), extracted from the basidiomycete Coriolus versicolor , and UFT at a dose of either 8 mg/kg or 12 mg/kg daily for 1 year. A total of 224 patients with poorly differentiated stage II–IV gastric cancer were entered into this study after undergoing a curative resection. No differences were observed between the two treatment groups in terms of prognostic factors, the toxicity rate or the doses of the drugs prescribed, other than UFT. The higher dose of UFT in maintenance therapy led to a decrease in the recurrence rate ( P