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Drug Abuse: Hedonic Homeostatic Dysregulation

Drug Abuse: Hedonic Homeostatic Dysregulation

  1. Spucky
    Understanding the neurobiological mechanisms of addiction requires an integration of
    basic neuroscience with social psychology, experimental psychology, and psychiatry.
    Addiction is presented as a cycle of spiralling dysregulation of brain reward systems that
    progressively increases, resulting in compulsive drug use and a loss of control over
    drug-taking. Sensitization and counteradaptation are hypothesized to contribute to this
    hedonic homeostatic dysregulation, and the neurobiological mechanisms involved, such
    as the mesolimbic dopamine system, opioid peptidergic systems, and brain and hormonal
    stress systems, are beginning to be characterized. This framework provides a
    realistic approach to identifying the neurobiological factors that produce vulnerability to
    addiction and to relapse in individuals with a history of addiction.

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