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Ecstasy: Pharmacodynamic and Pharmacokinetic Interactions (2004)

Ecstasy: Pharmacodynamic and Pharmacokinetic Interactions (2004)

  1. Jatelka
    Psychosomatics 2004 Jan-Feb;45(1):84-7.

    Oesterheld JR; Armstrong, Scott C. ; Cozza, Kelly L.

    At "raves," young people dance and ingest illicit drugs, the most common of which is MDMA (N-methyl-3,4,-methylenedioxymethamphetamine) or "ecstasy." This drug is metabolized principally through the cytochrome P450 (CYP450) 2D6 enzyme. Pharmacokinetic drug-drug interactions can occur if MDMA is combined with other recreational or therapeutic drugs that are 2D6 inhibitors. Ecstasy concentration may increase to cause toxicity. Since ecstasy is pro-serotonergic, it may also be involved in pharmacodynamic drug-drug interactions when other pro-serotonergic drugs are combined with it, leading to a central serotonin syndrome. Some drugs are both pro-serotonergic and CYP450 2D6 inhibitors and, if co-administered with ecstasy, may cause both pharmacokinetic and pharmacodynamic drug-drug interactions