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Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriola

Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriola

  1. Calliope
    Bulletin of Experimental Biology and Medicine, 1989, Vol.107(5), pp.668-670

    Mirzoyan, R. ; Gan'shina, T. ; Kosoi, M. ; Aleksandrin, V. ; Aleksandrov, P.

    Abstract
    Picamilon (nicotinoyl-γ-aminobutyric acid) is a cerebrovascular drug dietary supplement formed by combining niacin with GABA. It has been shown that picamilon increases cerebral blood flow in conscious animals, has a depressant effect on neurogenic spasm of cererbral vessels and restores the initial state of the cerebral hemodynamics when disturbed by a preliminary injection of serotonin. The aim of this investigation was to study the effect of picamilon on the local blood flow in the cerebral cortex and state of pial arteries of different diameter.