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Effect of Skin Permeability Enhancers on the Transdermal Introduction of Phenazepam in vitro

Effect of Skin Permeability Enhancers on the Transdermal Introduction of Phenazepam in vitro

  1. NeuroChi
    The growing interest in transdermal medicinal forms is related to their significant advantages such as the ability to prolong the action of the active drug component and stabilize its concentration on a constant level. This ensures a prolonged stationary pharmacological effect against the background of much less pronounced side effects [1]. In order to maintain the required concentration of a given drug in the organism, it is necessary to provide conditions for this drug to penetrate in sufficient amount through the horny
    layer of epidermis – the main barrier hindering penetration of foreign substances through the skin. Since most drugs are incapable of penetrating through the skin in sufficient amounts,
    there is a need to develop means for reversible control of the barrier properties of the horny layer. In connection with this, much attention is devoted to the search for effective skin permeability
    enhancers, capable of reversibly increasing the
    drug penetration, and to the study of the mechanisms of their action [2]. This work was aimed at determining the influence of
    some potential skin permeability enhancers upon transdermal introduction of phenazepam in vitro.
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