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Effectiveness of Buprenorphine in dual diagnosis

Effectiveness of Buprenorphine in dual diagnosis

  1. Spucky
    Opiate drugs were first proposed for the treatment of dysphoric syndromes,
    depression and psychoses many years ago. Even so, the usefulness of these
    compounds in psychiatry is supported by only a small corpus of data. The
    reasons given for the restrictions placed on opiate use are based on prejudice
    rather than scientific evidence. Buprenorphine, with its unique pharmacological
    profile, has proved to possess antidepressant, anti-dysphoric and antipsychotic
    properties in small groups of psychiatric patients. Moreover, it may turn out to
    be the opiate of choice in subjects affected by lower severity addiction coupled
    with dysthymic disorders, anxiety disorders and personality disorders. The best
    dosages appear to be those that ensure a combination of k-antagonism with high
    levels of μ-mediated stimulation.