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Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data

Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data

  1. Calliope
    British Medial Journal 2012; 345: (Published 17 December 2012)
    e8343doi:10.1136/bmj.e8343

    Tania B Huedo-Medina, Irving Kirsch, Jo Middlemass,Markos Klonizakis, A Niroshan Siriwardena

    Abstract
    To investigate the effectiveness of non-benzodiazepine hypnotics (Z drugs) and associated placebo responses in adults and to evaluate potential moderators of effectiveness in a dataset used to approve these drugs.
    Compared with placebo, Z drugs produce slight improvements in subjective and polysomnographic sleep latency, especially with larger doses and regardless of type of drug. Although the drug effect and the placebo response were rather small and of questionable clinical importance, the two together produced to a reasonably large clinical response.