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Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral th

Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral th

  1. Jatelka
    Pharmacol Biochem Behav 2005,81(3):485-496

    Jaehne EJ, Salem A, Irvine RJ


    3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') and related amphetamines such as para-methoxyamphetamine (PMA) disrupt normal thermoregulation in humans and rats. Behavior, an important component of thermoregulation in mammals, has not been investigated with respect to these drugs. This is surprising as harm minimization depends on appropriate thermoregulatory behavior by drug users. The effects of MDMA (10 mg/kg), PMA (10 mg/kg) and d-amphetamine (2 mg/kg) were therefore studied in Sprague-Dawley rats, with telemetry implants measuring core body temperature (T(C)), locomotor activity and heart rate. Rats were administered an amphetamine or saline and confined to an ambient temperature of 21, 30 or 15 degrees C for 30 min, before being able to choose their preferred temperature (T(P)) on a thermally graded runway (11-41 degrees C). Confinement at 21 degrees C had little effect on T(C) in any group. At 30 degrees C MDMA and PMA increased T(C) compared to saline (p