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Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in

Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in

  1. Pino
    Neuroscience Letters 1993 Apr 2;152(1-2):17-20

    Hashimoto K

    The reduction of 5-hydroxytryptamine (5-HT) in rat brain 3 h after administration of 3,4-methylenedioxymethamphetamine (MDMA) was attenuated significantly by coadministration of benzylpiperazine derivatives (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors of [3H]5-HT uptake into rat brain synaptosomes. However, the coadministration of desipramine and imipramine which were more potent 5-HT uptake inhibitors than these benzylpiperazines, did not attenuate the reduction of 5-HT by MDMA. These results suggest that these benzylpiperazines might inhibit the acute effects of MDMA by a novel neuropharmacological effect other than 5-HT uptake inhibition