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Effects of mitragynine from Mitragyna speciosa Korth leaves on working memory

Effects of mitragynine from Mitragyna speciosa Korth leaves on working memory

  1. NeuroChi
    Aimof the study: Mitragyna speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast
    Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives
    for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to
    hard work. However there is no scientific information about the effect of mitragynine on the cognitive
    performances. This study is designed to examine the working memory effects of mitragynine which is
    extracted from Mitragyna speciosa mature leaves.
    Materials and methods: The cognitive effect was studied using object location task and the motor activity
    in open-field test. Mitragynine 5, 10 and 15 mg/kg and were administered by intraperitoneal (IP) for 28
    consecutive days and evaluated on day 28 after the last dose treatment. Scopolamine was used as the
    control positive drug.
    Results: In this study there is prominent effects on horizontal locomotor activity was observed. Mitragynine
    significantly reduced locomotor activity in open-field test compared with vehicle. In object location
    task mitragynine (5, 10 and 15 mg/kg) did not showed any significances discrimination between the
    object that had changed position than the object that had remain in a constant position.
    Conclusion: Our results suggest that chronic administration of mitragynine can altered the cognitive
    behavioral function in mice.