EFFECTS OF URINARY pH ON AMPHETAMINE METABOLISM

effect of urinary pH on the rate of disappearance of amphetamine from plasma

  1. Diverboone
    Study Author(s):
    John M. Davis, M.D., Irwin J. Kopin, M.D., Louis Lemberger, M.D., and Julius Axelrod, Ph.D.
    Journal Name:
    Annals New York Academy of Sciences
    Publication Date:
    July 1971 Volume 179, Drug Metabolism in Man Pages 493–501
    PMID:
    5285389
    Since it is possible that the metabolism of amphetamine to pharmacologically important compounds is related to its plasma level or its rate of excretion, we examined the effect of urinary pH on the rate of disappearance of amphetamine from plasma and on the metabolic fate of this drug.