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Evidence for roles of κ-opioid and NMDA receptors in the mechanism of action of ibogaine

Evidence for roles of κ-opioid and NMDA receptors in the mechanism of action of ibogaine

  1. ThirdEyeFloond
    Brain Research
    Volume 749, Issue 2, 28 February 1997, Pages 340-343
    Stanley D. Glick, Isabelle M. Maisonneuve and Sandra M. Pearl

    Abstract

    Ibogaine, a putatively anti-addictive alkaloid, binds to κ-opioid and NMDA receptors. In the present study we investigated the roles of κ-opioid and NMDA actions in mediating ibogaine's (40 mg/kg, i.p.) behavioral and neurochemical effects in rats. A combination of a κ-opioid antagonist (norbinaltorphimine, 10 mg/kg, s.c.) and a NMDA agonist (NMDA, 20 mg/kg, i.p.) partially prevented ibogaine-induced inhibition of intravenous morphine self-administration and ibogaine-induced antagonism of morphine-induced locomotor stimulation. The combination, as well as norbinaltorphimine and NMDA alone, blocked the acute effects of ibogaine on dopamine release and metabolism in the striatum. The data suggest that both κ-opioid agonist and NMDA antagonist actions of ibogaine contribute to its putative anti-addictive effects.
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