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From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid (2004)

From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid (2004)

  1. Alfa
    TRENDS in Pharmacological Sciences Vol.25 No.1 January 2004

    C. Guin Ting Wong, K. Michael Gibson,and O. Carter Snead III

    g-Hydroxybutyric acid (GHB) is a short-chain fatty acid that occurs naturally in the mammalian brain and is formed primarily from the precursor g-aminobutyric acid (GABA). The properties of GHB suggest that it has a neuromodulatory role in the brain and has the ability to induce several pharmacological and behavioral effects. GHB has been used clinically as an anesthetic and to treat alcoholism and narcolepsy. Furthermore, GHB has emerged recently as a major recreational drug
    of abuse. GHB appears to have dual mechanisms of action in the brain. Biochemical data suggest that the intrinsic neurobiological activity of GHB might be mediated through the GHB receptor, which is separate and distinct from the GABA
    B receptor. However, many of the pharmacological and clinical effects of exogenously administered GHB, including the properties of addiction, tolerance, withdrawal and intoxication, are
    probably mediated via the GABA B receptor, where GHB might act both directly as a partial agonist and indirectly through GHB-derived GABA.

Recent Reviews

  1. psyche
    psyche
    5/5,
    Version: 2006-06-01
    Very enlightening and clear, but not too shallow.