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GABAA Receptor Activation Attenuates Excitotoxicity but Exacerbates Oxygen-Glucose Deprivation-Induc

GABAA Receptor Activation Attenuates Excitotoxicity but Exacerbates Oxygen-Glucose Deprivation-Induc

  1. catseye
    Judith K Muir, Doug Lobner, Hannelore Monyer, and Dennis W. Choi

    Journal of Cerebral Blood Flow Gild Metabolism
    16:1211-1218, 1996

    Summary: We examined the effects of GABA receptor stimulation on the neuronal death induced by exogenously added excitatory amino acids or combined oxygen-glucose deprivation in mouse cortical cell cultures. Death induced by exposure
    to NMDA, AMPA, or kainate was attenuated by addition of GABA or the GABAA receptor agonist, muscimol, but not by the GABAB receptor agonist, baclofen. The antiexcitotoxic effect of GABAA receptor agonists was blocked by bicuculline or
    picrotoxin. In contrast, GABA or muscimol, but not baclofen, markedly increased the neuronal death induced by oxygen glucose deprivation.