1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system (2004)

Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system (2004)

  1. Jatelka
    Polish Journal of Pharmacology 2004 Jan-Feb;56(1):43-9

    Waszkielewicz A, Bojarski J

    Gamma-hydroxybutyric acid (GHB) is a naturally occurring substance with function of an inhibitory neurotransmitter in the central nervous system in mammals. GHB can be used as a medicine in narcolepsy (Xyrem) and for general anesthesia (sodium oxybate). It is also a popular drug of abuse, causing coma, addiction and severe withdrawal syndrome, and, therefore, demanding thorough studies on the GHBergic system and expanded research on toxicology of this compound. The aim of this review is to present the proved and some suggested mechanisms of its action from pharmacological point of view, which may help to properly treat intoxication or other pathological states caused by GHB ingestion. Some new GHB derivatives studied for analogous action and their present use are also described.

    Discussion Thread

Recent Reviews

  1. bob_arctor
    bob_arctor
    4/5,
    Version: 2007-06-09
    Comprehensive and informative summary on the subject