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Grapefruit juice substantially increases plasma concentrations of buspirone

Grapefruit juice substantially increases plasma concentrations of buspirone

  1. chrisn
    Grapefruit juice considerably increased plasma buspirone concentrations. The probable mechanism of this interaction is delayed gastric emptying and inhibition of the cytochrome P450 3A4-mediated first-pass metabolism of buspirone caused by grapefruit juice. Concomitant use of buspirone and at least large amounts of grapefruit juice should be avoided.