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Hashish Importance of the Phenolic Hydroxyl Group in Tetrahydrocannabinols (1975)

Hashish Importance of the Phenolic Hydroxyl Group in Tetrahydrocannabinols (1975)

  1. Alfa
    Journal of Medicinal Chemistry 1975 Feb;18(2):213-5

    Uliss DB , Dalzell HC , Handrick GR , Howes JF, Razdan RK.

    Optically active delta-3- and delta-8-tetrahydrocannabinols (THC's), cannabidiol and racemic delta-9-cis-THC, and their corresponding analogs (1b yields 4b) in which the positions of the phenolic hydroxyl group and the n-C5 side chain have been interchanged are compared in selected pharmacological tests in mice. the results indicate that the phenolic hydroxyl group in the 1 position in THC's is very important for eliciting activity and that cannabidiol and delta-9-cis-THC possess weak CNS depressant properties.