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Heroin-Induced Alterations in Leukocyte Numbers and Apoptosis in the Rat Spleen (2000)

Heroin-Induced Alterations in Leukocyte Numbers and Apoptosis in the Rat Spleen (2000)

  1. mersann
    Authors: Karamarie Fecho and Donald T. Lysle


    Abstract beginning: The present study assessed the effects of acute heroin treatment on the cellularity of the rat spleen and the rate of splenocyte death by necrosis or apoptosis. The results showed that 1 h after a single injection of heroin, the total number of leukocytes in the spleen was decreased in a dose-dependent manner. Prior injection of naltrexone completely blocked heroin’s effect, and the heroin-induced decrease in splenic leukocytes was not associated with a heroin-induced increase in circulating leukocytes. A 1-h exposure to heroin did not increase levels of lactate dehydrogenase, a cytosolic enzyme, in supernatants of splenic mononuclear cells cultured for 45 min or 24 h, suggesting that heroin does not increase necrotic death in the spleen.