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Hyperforin in St. John’s wort drug interactions

Hyperforin in St. John’s wort drug interactions

  1. H Bomber
    Recently, interactions of herbal medicines with
    synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John’s wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with SJW resulted in decreased plasma concentrations of a
    number of drugs including amitriptyline, cyclosporine, digoxin, indinavir, irinotecan, warfarin, phenprocoumon, alprazolam, dextrometorphane, simvastatin, and oral contraceptives. Sufficient evidence from interaction studies and case reports indicate that SJW is a potent inducer of
    cytochrome P450 enzymes (particularly CYP3A4) and/or P-glycoprotein.