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Identification of Cytochrome P450 Enzymes Involved in the Metabolism of the New Designer Drug 4&#824

Identification of Cytochrome P450 Enzymes Involved in the Metabolism of the New Designer Drug 4&#824

  1. jon-q
    The cytochrome P450 (P450) family accounts for more than 90% of oxidative metabolic reactions of xenobiotics (Guengerich, 2005). The involvement of particular P450 enzymes in the biotransformation of a new chemical entity is usually thoroughly investigated before it can be marketed in order to assess the risk of increased side effects in poor metabolizer subjects and of drug-drug or drug-food interactions. However, such data are typically acquired for substances intended for therapeutic use, not for drugs of the illicit market.
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