1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Identification of Levamisole and Lidocaine Acetylation Reaction Impurities Found in Heroin Exhibits

Identification of Levamisole and Lidocaine Acetylation Reaction Impurities Found in Heroin Exhibits

  1. davestate
    Five (5) compounds were identified as impurities present in a heroin exhibit containing levamisole and lidocaine. Spectroscopic and chromatographic data are provided for characterization of these products. The presence of these impurities suggests that levamisole and lidocaine were added to morphine base prior to acetylation of morphine with acetic anhydride that produced heroin and the aforementioned compounds

    The Drug Enforcement Administration’s Special Testing and Research Laboratory conducted an analysis of an exhibit as a part of its Heroin Signature Program (HSP), and determined that the exhibit contained 78.4% heroin, 2.3% levamisole, 1.4% lidocaine, and other typical heroin-related alkaloids. In addition to the heroin, levamisole, and lidocaine identified in the exhibit, four other unidentified compounds of significant concentration and one compound at a trace level were observed. Examination of the total ion chromatographic profile indicated the presence of fragment ions for two of those compounds that appear to be related to levamisole impurities found in some cocaine exhibits