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Identification of Primary JWH-018 and JWH-073 Metabolites in Human Urine_Technical Bulletin_NMS Labs

Identification of Primary JWH-018 and JWH-073 Metabolites in Human Urine_Technical Bulletin_NMS Labs

  1. YIPMAN
    Original title:
    Technical Bulletin: Identification of Primary JWH-018 and JWH-073 Metabolites in Human Urine

    Barry K. Logan PhD, DABFT, Sherri L. Kacinko PhD,
    Matthew M. McMullin MS, DABFT, Allan Xu PhD,
    Robert A, Middleberg PhD, DABFT, DABCC

    NMS Labs 2011

    Introduction
    First developed to study the cannabinoid receptor system, various synthetic cannabinoid agonists are now being used recreationally as an alternative to cannabis. Marketed as “herbal incense” or “legal highs”, the chemical compounds are being sprayed onto inert plant substrates and smoked. The principal drugs in circulation in the United States in 2011 include JWH-018 and JWH-073, both of which have been placed in schedule I by the Drug Enforcement Administration (DEA)1.

    This technical bulletin, developed by NMS Labs in support of its forensic testing programs, documents the discovery of the identity of major monohydroxy metabolites for both drugs, through techniques including human liver microsomal incubation, analysis of authentic positive urine samples, and ultimately synthesis of the proposed metabolites and confirmation of their identity by various chromatographic, mass spectrometric, and nuclear magnetic resonance techniques.