1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.

Impairment of Performance Associated With Long-Term Use of Benzodiazepines (1995)

Impairment of Performance Associated With Long-Term Use of Benzodiazepines (1995)

  1. Jatelka
    The Journal of Psychopharmacology 9(4) (1995) 313-318

    Gorenstein et al

    The long-term effects of benzodiazepines (BDZ) on psychomotor and cognitive functions were assessed in 28 out-patients, users of low therapeutic doses of diazepam (13.6+/- 4.9 mg/day, range: 5-20 mg/day) for 5-20 years (10.1 +/- 5.0 years). These patients’ performance was compared with two control groups: 53 BDZ-free anxious out-patients and 56 healthy volunteers. The three groups were similar in sex, age and education. BDZ chronic users were tested before and after short-term (3 weeks) and long-term discontinuation (at an average of 10 months). Performance of chronic users of BDZ was consistently worse than those of the control groups, suggesting an impairment in these patients on both psychomotor and cognitive functions. These were not related to either dose or cumulative exposure to BDZ, and were also independent of diagnosis and levels of anxiety and depression. Moreover, these deficits were persistent as their performance failed to improve after drug discontinuation.

Recent Reviews

  1. Bajeda
    Version: 2008-01-12
    Nice article, any follow-ups or more recent research of this kind?