1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Indolealkylamine and phenalkylamine hallucinogens. Effect of alpha-methyl and N-methyl substituents

Indolealkylamine and phenalkylamine hallucinogens. Effect of alpha-methyl and N-methyl substituents

  1. Anonymous
    Biochem Pharmacol. 1983 Apr 1;32(7):1267-73.
    Glennon RA, Young R, Jacyno JM.

    Abstract

    Animals (rats), trained to discriminate the hallucinogenic agent 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant procedure, were challenged with various doses of several indolealkylamine and phenalkylamine derivatives. In both series, the alpha-methyl analogs were found to be more active than either their N-methyl or alpha-demethyl counterparts. Furthermore, when the activities of the optical isomers of DOM were compared with the activities of S-(+) and R-(-)-alpha-methyltryptamine (alpha-MeT), it was found that the more potent isomer of alpha-MeT (i.e. S) possessed the opposite absolute configuration of the more potent isomer of DOM (i.e. R). With respect to the mechanism of action of these agents, these findings are not inconsistent with a common site hypothesis.
Tags: